Where does “knottin” come from?

knottin (English) comes from English knot, from Middle English knotte, from Old English cnotta, from Proto-Germanic knuttô, from Proto-Indo-European gnod- — to bind.

knottin (English): Inhibitor cystine knot

Definitions

Inhibitor cystine knot

Ancestry of “knottin”, step by step

knottin traces back through two separate lines of ancestry.

via English knot

Step	Language	Word	Meaning
1	English	knot	A looping of a piece of string or of any other...
2	Middle English	knotte	knot, tie; binding, method of attachment, link;...
3	Old English	cnotta	knot
4	Proto-Germanic	knuttô	a knot
5	Proto-Indo-European	gnod-	to bind

via English in

Step	Language	Word	Meaning
1	English	in	Used to indicate location, inclusion, or position...
2	Middle English	in	Any kind of accomodation; particularly; A home or...
3	Old English	in	in; Alternative form of inn
4	Proto-West Germanic	*in	—

Every word from Proto-Indo-European gnod- →Every word from Proto-Germanic knuttô →Every word from Old English cnotta →