Where does “santo” come from?

santo (Portuguese) comes from Old Portuguese santo, from Latin sānctus, from Latin Iacobus, from Ancient Greek Ἰάκωβος, from Ancient Greek Ἰακώβ, from Hebrew יַעֲקֹב, from Hebrew עָקֵב — heel of the foot; heel.

santo (Portuguese): holy, sacred; pure, immaculate, undefiled;...